Veterinarians have experienced disturbing trends related to workplace-induced stress. This is partly attributed to high levels of compassion fatigue, the emotional strain of unalleviated stress from interactions with those suffering from traumatic events. This paper presents a three-stage hybrid model designed to study the dynamics of compassion fatigue in veterinarians. A discrete event simulation that represents the work environment is used to generate client and patient attributes, and the veterinarian’s utilization throughout the day. These values become inputs to a system dynamics model that simulates the veterinarian’s interpretation of the work environment to produce quantifiable emotional responses in terms of eight emotions. The emotional responses are mapped to the Professional Quality of Life Scale, which enables the calculation of compassion satisfaction, burnout, and secondary traumatic stress measures. A pilot study using the hybrid model was conducted to assess the viability of the proposed approach, which yielded statistically significant results.