Despite a high potential to improve the productivity, quality and safety and also to reduce costs, automated technologies are not widely spread in the construction sector. This paper presents a simulation-based approach to analyze the technical and economic feasibility of wire robots for automated construction in future investigations. Masonry buildings are considered as an appropriate application case due to repetitive construction procedures and high demands concerning accuracy of construction. A simulation model representing the fundamental mechanics of a wire robot is created. Special focus lies on creating collision-free motion profiles which can be exported to the robot control system. BIM models can be used to set-up the simulation model and to prepare the required input data. Following a modular structure, the model can be applied with different purposes in the exploration of the approach. The construction of a one-story masonry building serves as case study proving the concept’s functionality.