A Modern Simulation Approach for Pharmaceutical Portfolio Management Kirk Solo and Mark Paich. International Conference on Health Sciences Simulation (ICHSS'04), January 18 - 21, 2004, San Diego, California, USA

By creating an integrated simulation environment that models the underlying structure of a pharmaceutical enterprise portfolio it becomes possible to identify the optimal longitudinal allocation of finite resources across the constellation of available investment opportunities. The implementation of a hybrid approach that integrates multiple modeling techniques and analytic disciplines allows for a comprehensive environment that captures the underlying dynamics that drive observed market behavior. The implementation of an object oriented model structure constrains the models complexity by supporting dynamic re-use of both structure and logic.
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Agent Modeling of Hispanic Population Acculturation and Behavior Lyle Wallis, Mark Paich, and Andrei Borshchev. The 3rd International Conference on Systems Thinking in Management (ICSTM 2004), May 19 - 21, 2004, Philadelphia, Pennsylvania, USA

In recent US Census data widely reported in the press “Hispanics” have become the largest minority group in the US. Using simulation modeling technology we look at some of the structural forces that shape the characteristics of the Hispanic population. The model creates a simulated Hispanic population whose level of acculturation to the broader population of which it is a part dynamically varies according to individual choice. The modeling technique used draws on both System Dynamic and Agent based paradigms both supported by innovative AnyLogic software. The representative Hispanic population is disaggregated down to the individual level as individual agents. Each agent makes choices stochastically as modulated by its current state and the outside environment that it is in.
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A multi-paradigm, whole system view of health and social care for age-related macular degeneration Joe Viana, Stuart Rossiter, Andrew A. Channon, Sally C. Brailsford, Andrew Lotery, WSC-2012, Berlin

This paper presents a hybrid simulation model for the management of an eye condition called age-related macular degeneration, which particularly affects the elderly. The model represents not only the detailed clinical progression of disease in an individual, but also the organization of the hospital clinic in which patients with this condition are treated and the wider environment in which these patients live (and their social care needs, if any, are met). The model permits a ‘whole system’ societal view which captures the interactions between the health and social care systems
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Hybrid simulation with loosely coupled system dynamics and agent-based models for prospective health technology assessments Anatoli Djanatliev, Reinhard German, Peter Kolominsky-Rabas, Bernd M. Hofmann, WSC-2012, Berlin

Due to the ageing of the world population, the demand for technology innovations in healthcare is growing rapidly. All stakeholders (e.g., patients, healthcare providers and health industry) can take profit of innovative products, but the development degenerates often into a time consuming and cost-intensive process. Prospective Health Technology Assessment (ProHTA) is a new approach that combines the knowledge of an interdisciplinary team and uses simulation techniques to indicate the effects of new innovations early before the expensive and risky development phase begins. In this paper, we describe an approach with loosely coupled system dynamics and agent-based models within a hybrid simulation environment for ProHTA as well as a use-case scenario with an innovative stroke technology
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