Partial Paradigm Hiding and Reusability in Hybrid Simulation Modeling Using the Frameworks Health-DS and I7-Anyenergy A. Djanatliev, P. Bazan, R. German, University of Erlangen-Nuremberg. Winter Simulation Conference, 2014.

Many complex real-world problems which are difficult to understand can be solved by discrete or continuous simulation techniques, such as Discrete-Event-Simulation, Agent-Based-Simulation or System Dynamics. In recently published literature, various multilevel and large-scale hybrid simulation examples have been presented that combine different approaches in common environments.
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A Tripartite Hybrid Model Architecture for Investigating Health and Cost Impacts and Intervention Tradeoffs for Diabetic End-stage Renal Disease Amy Gao, Nathaniel D. Osgood, Wenyi An, Roland F. Dyck. Winter Simulation Conference, 2014.

Like most countries, Canada faces rising rates of diabetes and diabetic ESRD, which adversely affect cost, morbidity/mortality and quality of life. These trends raise great challenges for financial, human resource and facility planning and place a premium on understanding tradeoffs between different intervention strategies. We describe here our hybrid simulation model built to inform such efforts.
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A Modular Simulation Model For Assessing Interventions For Abdominal Aortic Aneurysms Christoph Urach, Günther Zauner, Gottfried Endel, Ingrid Wilbacher, Felix Breitenecker, Proceedings of the 2013 Winter Simulation Conference

This paper discusses the development of an individual based simulation of interventions for better treatment of patients with abdominal aortic aneurysms (AAA). The interdisciplinary subject required collaboration of medical doctors, Health Technology Assessment (HTA) experts and modelers.
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Prospective Healthcare Decision-Making By Combined System Dynamics, Discrete-Event And Agent-Based Simulation Anatoli Djanatliev, Reinhard German, Proceedings of the 2013 Winter Simulation Conference

Prospective Health Technology Assessment allows early decision making for innovative health care technologies. In our recent publications a hybrid simulation approach with System Dynamics and Agent-Based Modeling has been presented. This paper presents a mechanism to generate agents dynamically from SD models and extends the previously presented hybrid approach by process-oriented Discrete Event Simulation for hospital modeling.
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Large Scale Healthcare Modeling by Hybrid Simulation Techniques using AnyLogic Anatoli Djanatliev and Reinhard German, Computer Networks and Communication Systems Department of Computer Science 7. Proceedings of the 6th International ICST Conference on Simulation Tools and Techniques

This paper describes a methodical and practical approach of hybrid model creation using the simulation tool AnyLogic. We focus on general modeling aspects and on advanced techniques using a Level-Based Architecture that help to develop large scale hybrid simulation models. An implementation of a stroke therapy use-case and its simulation results will be discussed. Finally, some practical ideas for validation will be outlined, as we experienced during the stroke use-case development.
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